Sarms Mk-677/Mk677 Effect Uses and Dosage for Gian Muscle
|FOB Price:||US $1.5 / g|
|Min. Order:||10 g|
|Min. Order||FOB Price|
|10 g||US $1.5/ g|
|Payment Terms:||T/T, Western Union, Money Gram|
- Model NO.: Mk-677/MK677
- Customized: Non-Customized
- Suitable for: Adult
- Purity: >99%
- MW: 624.77
- Trademark: DMK
- Specification: API
- HS Code: 29061310
- Powder: Yes
- Certification: GMP, ISO 9001, USP
- State: Solid
- Mf: C28h40n4o8s2
- CAS: 159752-10-0
- Transport Package: Aluminum Foil Bag/Carton
- Origin: China
Bacis Introduction of MK-677:
MK-677 is an orally administered growth / hormone secretagogue originally developed by Reverse Pharmacology. A secretagogue is the term for a substance that chemically signals for the pituitary gland to secrete . In other words, MK-677 could be compared to peptides like GHRP-6 or Ipamorelin, only it doesn't require any injections nor does it have any side effects like GHRP-6. This GHS (Growth / Hormone Secretagogue) was developed in an aim to combat such conditions as muscle wasting, obesity and osteoporosis. It was also targeted towards treatment of elderly hip fracture patients, so there are a myriad of studies done on safety.,
MK-677 Basic Info.
MK-677 Ibutamoren mesylate 159752-10-0
Name : Ibutamoren mesylate
Systematic (IUPAC) name (R)-1'-(2-methylalanyl-O-benzyl-D-seryl)-1-(methylsulfonyl)-1,2-dihydrospiro[indole-3,4'-piperidine]
Molecular Weight : 624.77
Boiling Point : 868.9 °C at 760 mmHg
Flash Point : 479.3 °C
Other Name : Crescendo, UNII-R90JB6QJ2B
Appearance : white powder
Purity : ≥ 99.0%
Application : a growth hormone secretagogue, in the treatment of obesity
Mk677 / Mk-677 / Ibutamoren Ibutamoren (MK-677, L-163,191) is a drug which acts as a potent, orally active growth hormone secretagogue.
It is able to increase both muscle mass and bone mineral density. It also alters metabolism of body fat and so may have application in the treatment of obesity.
Ibutamoren (INN) (MK-677, MK-0677, L-163,191) is a non-peptidic, potent, long-acting, orally-active, and selective agonist of the ghrelin receptor and a growth hormone secretagogue,mimicking the growth/hormone (GH)-stimulating action of the endogenous hormone ghrelin.
It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including GH and insulin-like growth factor 1 (IGF-1), but without affecting cortisol levels.MK677 has shown to sustain activation of GH-IGF-1 Axis and increase in lean body mass but no change in total fat mass or visceral fat.
It is currently under development as a potential treatment for reduced levels of these hormones, such as in children or elderly adults with growth hormone deficiency,and human studies have shown it to increase both muscle mass and bone mineral density,making it a promising therapy for the treatment of frailty in the elderly.
Nutrobal (Mk-677) is an orally administrated growth hormone secretagogue originally developed by Reverse Pharmacology. A secretagogue is the term for a substance that chemically signals for the pituitary gland to secrete growth hormone. In other words, Nutrobal could be compared to peptides like GHRP-6 or Ipamorelin, only it doesn't require any injections nor does it have any side effects like GHRP-6. This GHS (Growth Hormone Secretagogue) was developed in an aim to combat such conditions as muscle wasting, obesity and osteoporosis. It was also targeted towards treatment of elderly hip fracture patients, so there are a myriad of studies done on safety.
In a study on it's effects on catabolic states, a once daily oral dose of 25mgs was given to healthy young men subjected to short-term diet-induced nitrogen wasting. After 7 days of this dose, the subjects showed a sustained increase in serum concentration of IGF-1 and Growth Hormone; in addition, the nitrogen wasting was reversed, showing great potential for treatment of conditions involving muscle wasting.
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Sarms Mk-677/MK677 Effect Uses and Dosage for Gian Muscle