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Wuhan Demeikai Biotechnology Co., Ltd.

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Supplier Homepage Product ADCs Chinese Manufacturer Bkm120 Powder for The Pan-Pi3K Inhibition CAS: 944396-07-0

Chinese Manufacturer Bkm120 Powder for The Pan-Pi3K Inhibition CAS: 944396-07-0

FOB Price: US $1.5 / g
Min. Order: 10 g
Min. Order FOB Price
10 g US $1.5/ g
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Port: Shanghai, China
Production Capacity: 100kg/Y
Payment Terms: T/T, Western Union, Money Gram

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Basic Info
  • Model NO.: Bkm120
  • Customized: Non-Customized
  • Suitable for: Adult
  • Purity: >99%
  • MW: 410.39400
  • Trademark: DMK
  • Specification: API
  • HS Code: 29061310
  • Powder: Yes
  • Certification: GMP, ISO 9001, USP
  • State: Solid
  • Mf: C18h21f3n6o2
  • CAS: 944396-07-0
  • Transport Package: Aluminum Foil Bag/Carton
  • Origin: China
Product Description
Chinese Manufacturer Bkm120 Powder for The Pan-Pi3k Inhibition CAS: 944396-07-0
Chinese Manufacturer Bkm120 Powder for The Pan-Pi3k Inhibition CAS: 944396-07-0

Buparlisib Basic Info.
Synonyms:5-(2,6-Dimorpholinopyrimidin-4-yl)-4-(trifluoromethyl)pyridin-2-amine; BKM120; NVP-BKM120; 
CAS:944396-07-0 
MF:C18H21F3N6O2 
MW:410.39400 
Purity:99.5%
Usage:Just for research

 
Description 
BKM120 (NVP-BKM120, Buparlisib) is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM in cell-free assays, respectively. Reduced potency against VPS34, mTOR, DNAPK, with little activity to PI4Kβ. Phase 2.
BKM120 is not sensitive to Class III and Class IV PI3K's or PI4K. NVP-BKM120 shows great antiproliferation activity to PI3K deregulated cell lines including A2780, U87MG, MCF7 and DU145 with GI50 of 0.1-0.7 nM.  BKM120 induces multiple myeloma cells (ARP1, ARK, MM.1S, MM1.R and U266) apoptosis, which results in increased G1-phase cells and decreased S-phase cells. BKM120 induced CD138+ primary MM cell apoptosis and has significant lower cytotoxicity toward CD138 stromal cells. BKM120 exposure could cause upregulation of BimS and downregulation of XIAP.  BKM120 demonstrates antiproliferative activity in human gastric cancer cell lines by decreasing mTOR downstream signaling. BKM120 could increase either p-ERK or p-STAT3 in KRAS mutant gastric cancer cells. Combination with STAT3 blockade, BKM120 shows a synergism in cells harboring mutated KRAS by inducing apoptosis, but not in KRAS wild-type cells.  A recent study shows that BKM120 shows differential forms of cell death on the basis of p53 status of the cells with p53 wild-type cells undergoing apoptotic cell death and p53 mutant/deleted cells having a mitotic catastrophe cell death. BKM120 mediates mitotic catastrophe mainly through Aurora B kinase. 
 
 
Application
The effect of the pan-PI3K inhibition, mediated by increased concentrations of buparlisib on MM cell survival was tested by MTT assay. Buparlisib induced cell toxicity after 48 hr treatment in all MM cell lines tested; with an IC50 between 0.5 and 1 μM. In addition, buparlisib decreased the activation of signaling proteins downstream of PI3K including pAkt, pS6R, pP70S6K, and p-mTOR in MM.1S cells in a dose dependent manner. 
Treatment of mice with buparlisib significantly decreased the rate of tumor progression compared with the vehicle treated group, as shown in representative images of the BLI and quantification of the BLI. These results were further confirmed by fluorescence microscopy, showing that the number of MM.1S- GFP+/luc+ cells present in the BM of mice treated with buparlisib decreased significantly compared with those present in the BM of mice treated with vehicle, as shown in representative images of immunofluorescence. 

 
Wuhan Deme chem Biotechnology Co., Ltd is a new and high-tech enterprise. 
The main business is research and development, production, sales for Steroid, Active ingredient and Pharmaceutical .
   

The list of cortical hormone drugs is as follows:
NamestandardCAS
Prednisolon AcetateUsp32 /ep652-21-1
Prednisolon BaseBp2010/Usp32/Ep750-24-8
PrednisonUsp321953/3/2
Prednison AcetateCp2005125-10-0
Betamethasone BaseEp6378-44-9
BetamethaasoneUsp325593-20-4
Dipropionate  
BudesonideEp551333-22-3
Clobetasol PropionateUsp3425122-46-7
Cortisone Acetateenterprise standard1950/4/4
   
Dexamethasone Sodium PhosphateEP62392-39-4
   
Fluocinolone AcetonideUsp3267-73-2
FluocinonideUsp32/CP356-12-7
HydrocortisoneEp750-23-7
Desonideenterprise standard638-94-8
Hydrocortisone AcetateEp71950/3/3
Dexamethasone AcetateEP61177-87-3
Triamcinol0ne acetonide acetateenterprise standard3870/7/3
Triamcinol0n AcetonideBP/USP/EP76-25-5
Triamcinol0ne BaseBP/USP/EP124-94-7
HalcinonideCp20053093-35-4
16α-Hydroxy-Prednisoloneenterprise standard13951-70-7


Reason to choose us 

.Guarantee the quality of products ,our Pharmaceutical Intermediate purity≥99% .

.Variety diversification & Adequate stock make sure we could meet your require

.Professional service and rich experience ,we also could give you some advise about 
please feel free to contact us if you have any question.

Payment Term:T/T  , Moneygram , Western Union.

Delivery

1. Sent out in 24hours once payment comfirm.

2. Professional agent make sure our ship fastly and safety

3.Offer your tracking number to you once we get it ,in order to facilitate you track the express
 
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