Best Quality&Good Price Mmad Inhibitor of Tubulin CAS: 203849-91-6
|FOB Price:||US $1.5 / g|
|Min. Order:||10 g|
|Min. Order||FOB Price|
|10 g||US $1.5/ g|
|Payment Terms:||T/T, Western Union, Money Gram|
- Powder: Yes
- Certification: GMP, ISO 9001, USP
- State: Solid
- Mf: C41h66n6o6s
- CAS: 203849-91-6
- Transport Package: Aluminum Foil Bag/Carton
- Origin: China
- Customized: Non-Customized
- Suitable for: Adult
- Purity: >99%
- MW: N/a
- Trademark: DMK
- Specification: API
- HS Code: 29061310
Product name:MonoMethyl Dolastatin 10
Synonyms:DeMethyldolastatin 10;MMAD;MonoMethyl Dolastatin 10;MonoMethylauristatin D;(S)-N-((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)amino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide
General tips:For obtaining a higher solubility , please warm the tube at 37 ºC and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20ºC for several months.
MMAD is a highly potent inhibitor of tubulin . MMAD is one of the auristatins, which are used as the drugs of antibody drug conjugates (ADCs). In ADCs, the therapeutic compounds and the high selectivity of antibodies are combined by the linkers. By taking advantage of antigen-selectivity of MAbs, it can deliver these cytotoxic drugs to antigen-expressing tumor cells, thus increasing both the efficacy and safety of therapy. As a payload of ADCs, MMAD is used to target the tubulin of the tumor cells. It can interfere with tubulin polymerization and induce rapid cell death at low picomolar concentrations . Additionally, MMAD is reported to be used in the production of site-specific antibody drug conjugates (NDCs). In the NDCs, MMAD is combined with anti-5T4 antibody or anti-Her2 antibody. It is shown that the NDCs demonstrate better efficacy and pharmacokinetics .
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MMAD packing :
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