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Wuhan Demeikai Biotechnology Co., Ltd.

Vapreotide Acetate, Melanotan I, Melanotan II manufacturer / supplier in China, offering Polypeptide Vapreotide Acetate Peptides Steroids CAS103222-11-3, Mepivacaine Hydrochloride CAS 1722-62-9 Reliver Pain Local Anesthesia Drugs, Pharmaceutical Chemicals Methyldrostanolone/Superdrol Steroids Powder Strengthen Muscle Strength and so on.

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Supplier Homepage Product Peptides Polypeptide Vapreotide Acetate Peptides Steroids CAS103222-11-3

Polypeptide Vapreotide Acetate Peptides Steroids CAS103222-11-3

Purchase Qty.:
(g)
10-99 100+
FOB Unit Price: US $1.5 US $0.8
Purchase Qty. (g) FOB Unit Price
10-99 US $1.5
100+ US $0.8
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Port: Shanghai, China
Production Capacity: 500kg/M
Payment Terms: T/T, Western Union, Money Gram

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Basic Info
  • Model NO.: DMK1105
  • Customized: Non-Customized
  • Suitable for: Elderly, Adult
  • Purity: >99%
  • MW: 1131.40
  • Trademark: DMK
  • Specification: API
  • HS Code: 29061310
  • Powder: Yes
  • Certification: GMP, ISO 9001, USP, BP
  • State: Solid
  • Mf: C57h70n12o9s2
  • CAS: 103222-11-3
  • Transport Package: Vials Packaged
  • Origin: China
Product Description
Polypeptide Vapreotide Acetate Peptides Steroids CAS103222-11-3
Vapreotide Acetate
Sequence: D-Phe-[Cys-Tyr-D-Trp-Lys-Val-Cys]-Trp-NH2
Alias:Sanvar,RC-160;VAPREOTIDE;D-PHE-CYS-TYR-D-TRP-LYS-VAL-CYS-TRP-NH2; Octastatin;
FCYWKVCW-NH2;D-Phe-L-Cys(1)-L-Tyr-D-Trp-L-Lys-L-Val-L-Cys(1)-L-Trp-NH2;
Cas No.: 103222-11-3
Molecular Formula: C57H70N12O9S2
Molecular Weight: 1131.40
Purity (HPLC): 98.0%
Appearance: White powder
Single Impurity(HPLC): 1.0%
Amino Acid Composition: 10% of theoretical
Peptide Content(N%): 80%(by %N)
Water Content(Karl Fischer): 6.0%
Acetate Content(HPIC): 15.0%
Mass Balance: 95.0~105.0%
Grade : Pharmaceutical Grade
Storage: Closed, below 2 ~ 8oC preservation 
Delivery time : within 24hours upon receipt of payment 
Delivery: EMS, DHL, TNT, FedEx, UPS
Usage : The drug can be used for treatment of early acute esophageal variceal bleeding (EVB) and endoscopic interventional therapy before hemostasis, can also be bleeding within 5 d lens for the treatment and prevention of recurrence after endoscopic.vapreotide acetate will be the only approved treatment for esophageal variceal bleeding in the United States. 


2.Description:
Variceal bleeding is a life-threatening complication of portal hypertension. The recommended treatment includes the early administration of a vasoactive drug. Vapreotide is a somatostatin analogue with a different receptor affinity to octreotide. It decreases portal pressure and blood flow of collateral circulation in rats with cirrhosis. The pivotal study of early administration of vapreotide in patients with cirrhosis and variceal bleeding has shown a significant improvement in bleeding control and, in the subset of patients with significant bleeding, a significant reduction in mortality. In addition, a meta-analysis of four randomized studies has shown a significant improvement in bleeding control. Vapreotide administrated via the intravenous route is simple to use, with practically no contraindications and few, usually minor, side effects.



3.Application:
The immediate release formulation of Sanvar, a somatostatin analogue, is used in the treatment of acute esophageal variceal bleeding (EVB).
Sanvar is used prior to endoscopic intervention to control haemorrhage and prevent re-bleeding during the critical five days following the onset of bleeding. EVB is a life threatening condition and the mortality rate is high (about 15% to 25%) in the first six weeks following the haemorrhage. EVB is the cause of about 70% of gastro-intestinal bleeding in patients suffering from liver cirrhosis.
Sanvar (vapreotide acetate) is a synthetic octapeptide analogue of the naturally-occurring somatostatin hormone. It has similar pharmacological properties to native somatostatin, but exhibits a longer duration of action. It is the only somatostatin analogue to have demonstrated statistically significant benefits in the early treatment of EVB in association with endoscopic therapy, in a placebo-controlled clinical study (Calès et al. New England Journal of Medicine, 2001). Control of bleeding with survival at five days was achieved more often with Sanvar (p=0.021) than with placebo. Additional Phase III trials have been completed in Europe in this indication. Sanvar can be stored at room temperature, an advantage over other products requiring refrigeration, allowing immediate administration, a key benefit in a life-threatening situation. The product has been granted orphan drug status in the U.S., where there is currently no FDA approved treatment for this indication.



COA:
Product NameVapreotide Acetate
SequenceD-Phe-[Cys-Tyr-D-Trp-Lys-Val-Cys]-Trp-NH2
Cas No.103222-11-3
Molecular FormulaC57H70N12O9S2
Molecular Weight1131.4
Purity (HPLC)98.00%
AppearanceWhite powder
Single Impurity(HPLC)1.00%
Amino Acid Composition10% of theoretical
Peptide Content(N%)80%(by %N)
Water Content(Karl Fischer)6.00%
Acetate Content(HPIC)15.00%
Mass Balance95.0~105.0%





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Our Advantage:

1.We have stock so we can delivery quickly at the very day when receive the payment.

2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order.

3.High quality guarenteed, once any problem is found, the package would be reshipped for you

4.Shipping by express (FedEx,UPS,DHL,EMS TNT HKEMS), by air . The most professional forwarder would be recommanded for you.

5 . Warm aftersale service for you 24/7 . Any of your question would be solved for the first as soon as possible . Adhering to the principle of customer first conviction . we will provide the best and the most sincere services as possible as we can.



Delivery Note:

•  Sent out in 24hours once payment comfirm.

•  Professional agent make sure our ship fastly and safety

• Offer your tracking number to you once we get it ,in order to facilitate you track the express

FAQ
1.How about parcel delivery success rate ?

Our goods packing will not contain any hormone information and can be sent out from different areas of china. At present,the goods customs clearance rate we send to United states and Europe is 99%. As for Canada, Brazil of quite high buckle close rate area, we also have a new way to get through the customs. We also have completely re-send policy to some areas.

2.What is The Minimum And Maximum Amount Of Steroid Powder I Can Order At One Time?

Normally, our min.order quantity is 10g,please feel free to contact us about the specific order.
We suggest the net weight of each package should be less than 3.5kg. But if your order quantity is more than 3.5 kg, we will split the goods into several packages and then send you separately.

3.Do You Ship Over The Weekend?

We use EMS,TNT,FEDEX,DHL four kinds of couriers. EMS don't collected parcels over the weekend. The packages can be shipped out normally before 12:00 a.m in Beijing time if you choose to ship by TNT or FedEx.
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